Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis - Takeaways - MDSpire

Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis

  • By

  • Yunfei Ma

  • Wanming Qu

  • June 11, 2026

  • 0 min

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  • 1

    Botulinum toxin type A (BoNT-A) is increasingly used as an adjunctive treatment in multimodal scar management strategies.

  • 2

    A systematic review and meta-analysis included six randomized controlled trials evaluating BoNT-A's effectiveness in scar management.

  • 3

    Pooled analysis indicated that BoNT-A significantly improved scar appearance, with a Mean Difference of -1.80 for the VSS score.

  • 4

    The evidence regarding BoNT-A's benefits in scar management is considered low-certainty and reflects heterogeneous treatment paradigms.

  • 5

    Further high-quality, standardized randomized controlled trials are needed to confirm the role of BoNT-A in scar management.

Original Source(s)

Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis

  • by Yunfei Ma, Wanming Qu

  • June 11, 2026

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