Correlation between nerve conduction velocity abnormality patterns and clinical severity grading in chemotherapy-induced peripheral neuropathy: a retrospective cohort study

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Chemotherapy-induced peripheral neuropathy (CIPN) affects 30% to 70% of patients receiving neurotoxic chemotherapy, significantly impacting quality of life.
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Sural sensory nerve action potential (SNAP) amplitude inversely correlates with CIPN severity, with a strong association observed at end-of-treatment.
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A relative decline in SNAP amplitude of ≥35% from baseline indicates a high likelihood of Grade ≥2 CIPN, with an AUC of 0.872.
4

Patients needing dose modifications exhibited greater early reductions in SNAP amplitude compared to those without treatment changes.
5

The study supports using serial large-fiber NCS, particularly sural SNAP amplitude, as objective measures of CIPN severity in clinical practice.

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