Identification and validation of core oxidative phosphorylation-related genes as biomarkers for immune response and diagnosis in burn injury - Takeaways - MDSpire
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Discovery and validation of essential oxidative phosphorylation-associated genes as indicators for immune response and diagnostic purposes in burn injuries

  • By

  • Jiaqi Xu

  • Yujie Cui

  • Kangdi Li

  • Jia Jia

  • Xinfeng Huang

  • August 12, 2026

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  • 1

    The study identified 23 differentially expressed oxidative phosphorylation-related genes in burn patients.

  • 2

    Three core genes, ATP6V1C1, ECHS1, and LDHA, were significantly associated with burn progression and immune response.

  • 3

    Distinct immune cell compositions were observed in burn patients, indicating varied immune activity between patient cohorts.

  • 4

    In vitro experiments showed that knockdown of ATP6V1C1 or LDHA reduced pro-inflammatory cytokine secretion.

  • 5

    A diagnostic nomogram based on the core genes demonstrated strong diagnostic capability for burn injuries.

Original Source(s)

Identification and validation of core oxidative phosphorylation-related genes as biomarkers for immune response and diagnosis in burn injury

  • by Jiaqi Xu, Yujie Cui, Kangdi Li, Jia Jia, Xinfeng Huang

  • August 12, 2026

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