The Emerging Role of Immunothrombosis in the Control and Pathogenesis of Mycobacterium tuberculosis

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Immunothrombosis plays a crucial role in the immune response to Mycobacterium tuberculosis by trapping the bacteria to prevent its dissemination.
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Dysregulated immunothrombosis may contribute to tuberculosis pathogenesis, leading to drug resistance and lung damage.
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Coagulopathy is common in tuberculosis, with elevated levels of coagulation factors indicating the presence of microthrombosis.
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Tissue factor (TF) is upregulated in TB, playing a significant role in coagulation activation and potentially controlling Mtb growth.
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Further research into immunothrombosis mechanisms may lead to host-directed therapies to reduce tissue destruction and combat drug resistance.

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