Cognitive Function and Fatigue in Stable Multiple Sclerosis: EDSS and MRI Assessments Surpass Serum Biomarkers - Takeaways - MDSpire

Cognitive Function and Fatigue in Stable Multiple Sclerosis: EDSS and MRI Assessments Surpass Serum Biomarkers

  • By

  • Deborah K. Erhart

  • Luisa T. Balz

  • Roland Opfer

  • Lothar Spies

  • Franziska Bachhuber

  • Ioannis Vardakas

  • Daniela Taranu

  • Stefanie Jung

  • Tanja Fangerau

  • Makbule Senel

  • Kornelia Kreiser

  • Ingo Uttner

  • Dorothée Lulé

  • Hayrettin Tumani

  • April 17, 2026

  • 0 min

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  • 1

    Cognitive impairment and fatigue are prevalent in multiple sclerosis, affecting 34-65% and up to 95% of patients, respectively.

  • 2

    EDSS primarily reflects physical disability, with limited representation of cognitive impairment and fatigue, which decline with increasing EDSS.

  • 3

    MRI biomarkers, particularly volumetric measures of deep grey matter, are linked to cognitive decline and fatigue in multiple sclerosis patients.

  • 4

    Serum biomarkers like sNfL and sGFAP show limited predictive value for cognition and fatigue in stable relapsing-remitting multiple sclerosis.

  • 5

    The study aims to explore associations between imaging, serum biomarkers, EDSS, cognition, and fatigue in a cohort of stable RRMS patients.

Original Source(s)

Cognitive Function and Fatigue in Stable Multiple Sclerosis: EDSS and MRI Assessments Surpass Serum Biomarkers

  • by Deborah K. Erhart, Luisa T. Balz, Roland Opfer, Lothar Spies, Franziska Bachhuber, Ioannis Vardakas, Daniela Taranu, Stefanie Jung, Tanja Fangerau, Makbule Senel, Kornelia Kreiser, Ingo Uttner, Dorothée Lulé, Hayrettin Tumani

  • April 17, 2026

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