The role of NAD+ metabolic reprogramming in colorectal cancer chemoresistance: mechanistic insights, clinical translation challenges and opportunities - Takeaways - MDSpire

The role of NAD+ metabolic reprogramming in colorectal cancer chemoresistance: mechanistic insights, clinical translation challenges and opportunities

  • By

  • Zhennan Ma

  • Xiuqing Gong

  • Fuquan Liu

  • May 28, 2026

  • 0 min

Share

  • 1

    NAD+ metabolic reprogramming plays a critical role in colorectal cancer chemoresistance by regulating energy metabolism and DNA repair.

  • 2

    Key molecules such as NAMPT, SIRT1, and PARP are involved in the dysregulation of NAD+ pathways that contribute to chemoresistance.

  • 3

    Targeted interventions against NAD+ metabolism, including precursor supplementation and inhibitors, show potential for reversing chemoresistance.

  • 4

    Clinical translation of NAD+ targeting strategies is challenged by tumor metabolic heterogeneity and insufficient monitoring technologies.

  • 5

    Emerging techniques like multi-omics integration and organoid models may help develop personalized interventions for colorectal cancer.

Original Source(s)

The role of NAD+ metabolic reprogramming in colorectal cancer chemoresistance: mechanistic insights, clinical translation challenges and opportunities

  • by Zhennan Ma, Xiuqing Gong, Fuquan Liu

  • May 28, 2026

Related Content

Recurrent pleuropulmonary blastoma type III initially misclassified as embryonal rhabdomyosarcoma on limited biopsy: a case report with pathogenic DICER1 variant

High-grade astrocytoma with piloid features: a case report of comprehensive management

Beyond inhibition: harnessing the DRD2–VEGF-A feedback loop for precision anti-angiogenesis therapy in cancer