Clinical value of first-morning urine exfoliated cell HPV detection in the diagnosis of high-grade cervical lesions

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The study enrolled 500 women from four institutions in Ningxia, China, to evaluate first-morning urine (FMU) HPV testing for cervical lesions.
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FMU HPV detection rates were significantly higher in cervical cancer and high-grade lesions compared to low-grade lesions and no lesions.
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FMU testing demonstrated comparable sensitivity and specificity to traditional cervical testing for detecting CIN2+ lesions.
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Participant compliance and satisfaction were significantly higher for FMU testing compared to traditional cervical testing.
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The study supports FMU HPV testing as a promising non-invasive option, pending further validation in average-risk screening populations.

Frontiers In Oncology

by Fang Li, Lihua Pei, Juan Lv, Mingfu Jiang, Hui Yang, Hailan Ma, Ning Zhou, Lingfei Li, Ying Luo, Zhengfu Wang, Haifeng Jiang, Na Zhao
July 8, 2026

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