Editorial: The role of immune and stromal mediators in the formation of pre-metastatic and metastatic niches: the gateway to metastasis - Takeaways - MDSpire

Editorial: The role of immune and stromal mediators in the formation of pre-metastatic and metastatic niches: the gateway to metastasis

  • By

  • Michal A. Rahat

  • Dalit Barkan

  • Adit Ben-Baruch

  • June 18, 2026

  • 0 min

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  • 1

    Metastasis remains a significant clinical challenge in cancer treatment due to its treatment resistance and late detection.

  • 2

    Stromal and immune interactions play crucial roles in the formation of pre-metastatic and metastatic niches, influencing tumor cell behavior.

  • 3

    Organ-specific characteristics shape the immune microenvironment, affecting the efficacy of immunotherapy in metastatic cancers.

  • 4

    Platelets and their extracellular vesicles contribute to immune evasion and metastatic niche formation by altering tumor microenvironments.

  • 5

    Signaling pathways like CXCL12/CXCR4 and CD147 are key drivers of tumor progression and immune evasion in metastatic cancers.

Original Source(s)

Editorial: The role of immune and stromal mediators in the formation of pre-metastatic and metastatic niches: the gateway to metastasis

  • by Michal A. Rahat, Dalit Barkan, Adit Ben-Baruch

  • June 18, 2026

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