Host TLR4 activation by tenascin-C is associated with MMP14-dependent glioma invasion - Takeaways - MDSpire
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Activation of Host TLR4 by Tenascin-C Correlates with MMP14-Driven Invasion in Gliomas

  • By

  • Hannah Haneke

  • Ibrahim E. Efe

  • Omar Dzaye

  • Helmut Kettenmann

  • Fatih Yalcin

  • September 8, 2026

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  • 1

    Glioblastoma is characterized by diffuse invasion and remodeling of the tumor microenvironment, primarily influenced by tumor-associated myeloid cells.

  • 2

    Tenascin-C (TNC) is upregulated in glioblastoma and acts as an endogenous ligand for Toll-like receptor 4 (TLR4) in host myeloid cells.

  • 3

    Activation of TLR4 by TNC correlates with increased expression of matrix metalloproteinase 14 (MMP14), promoting glioma invasion.

  • 4

    High expression levels of TNC and MMP14 in glioma are associated with shorter overall survival in patients.

  • 5

    Loss of TLR4 in organotypic brain slices reduces glioma expansion and infiltrative behavior, indicating its role in tumor invasion.

Original Source(s)

Host TLR4 activation by tenascin-C is associated with MMP14-dependent glioma invasion

  • by Hannah Haneke, Ibrahim E. Efe, Omar Dzaye, Helmut Kettenmann, Fatih Yalcin

  • September 8, 2026

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