IGFBP-6 regulates SH2D4A expression to promote breast cancer cell cycle progression in response to progesterone - Takeaways - MDSpire

IGFBP-6 regulates SH2D4A expression to promote breast cancer cell cycle progression in response to progesterone

  • By

  • Francisco J. Lariz

  • Diana C. Bautista-Tovar

  • Alejandro Lazo-Loya

  • Kevin D. Houston

  • June 30, 2026

  • 0 min

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  • 1

    IGFBP-6 is induced by progesterone in breast cancer cells and regulates the progesterone receptor via negative feedback.

  • 2

    Proteomic analysis revealed that knockdown of IGFBP-6 alters the expression of 43 proteins in response to progesterone treatment.

  • 3

    SH2D4A induction by progesterone is dependent on high levels of IGFBP-6, and its knockdown leads to cell cycle arrest in G1.

  • 4

    Both IGFBP-6 and SH2D4A are involved in regulating cyclin B, impacting cell cycle progression in breast cancer cells.

  • 5

    The study identifies a pathway linking progesterone, IGFBP-6, and SH2D4A to cell cycle advancement in breast cancer.

Original Source(s)

IGFBP-6 regulates SH2D4A expression to promote breast cancer cell cycle progression in response to progesterone

  • by Francisco J. Lariz, Diana C. Bautista-Tovar, Alejandro Lazo-Loya, Kevin D. Houston

  • June 30, 2026

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