ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review - Takeaways - MDSpire

ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

  • By

  • Kailin Guo

  • Chang Hu

  • Le Li

  • Xiao Liu

  • Yaohui Liu

  • Dongsu Zhang

  • Yujie Fang

  • Yiming Li

  • Bo Hu

  • October 8, 2025

  • 0 min

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  • 1

    Sepsis is a life-threatening condition with significant mortality, primarily due to vascular endothelial injury and microcirculatory dysfunction.

  • 2

    Decreased levels of ApoA1 and HDL during sepsis correlate with increased vascular permeability and endothelial dysfunction, impacting patient outcomes.

  • 3

    ApoA1 serves as an independent predictor of mortality in sepsis, with its reduction linked to severe infections, including bacterial and viral.

  • 4

    Exogenous supplementation of HDL or ApoA1 can ameliorate vascular endothelial injury, enhancing endothelial regeneration and reducing inflammation.

  • 5

    Therapeutic strategies targeting ApoA1/HDL levels may provide critical interventions for managing sepsis-related vascular complications.

Original Source(s)

ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

  • by Kailin Guo, Chang Hu, Le Li, Xiao Liu, Yaohui Liu, Dongsu Zhang, Yujie Fang, Yiming Li, Bo Hu

  • October 8, 2025

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