Case Definitions and Data Sources for NNCSS Parkinson Disease Surveillance: A Systematic Review

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Parkinson disease (PD) is a prevalent neurodegenerative disorder that poses significant challenges for accurate diagnosis.
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An estimated 700,000 US residents live with PD, with higher prevalence in males and increasing age.
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The National Neurological Conditions Surveillance System (NNCSS) was established to improve surveillance and research on neurological conditions, including PD.
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The systematic review identified 156 eligible studies, focusing on case definitions and data sources for PD surveillance.
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Most studies utilized administrative data, with Medicare being the most common data source for PD research in the US.

Jama Network Open

by Christine D. Esper, Kelly N. Hogan, Purni Abeysekara, Kasey Nichole Smith, Tenbroeck G. Smith, Shawna L. Mercer
June 8, 2026

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