CEBP-altered B-ALL: Two transcriptomic profiles across the age spectrum - Takeaways - MDSpire
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CEBP-Altered B-ALL Across Ages: Two Distinct Transcriptomic Profiles

  • By

  • Jacqueline A. Rehn

  • Ashlee J. Thomson-Roberts

  • David T. Yeung

  • Deborah L. White

  • Elyse C. Page

  • October 17, 2026

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  • 1

    Whole-transcriptome sequencing separated 24 CEBP-altered B-ALL cases into two distinct transcriptomic clusters across pediatric, AYA, and adult patients.

  • 2

    Cluster A aligned with CEBP/ZEB2 and was enriched for ZEB2 p.H1038R, NRAS mutations, and CDKN2A deletions.

  • 3

    Cluster B aligned with CEBPalt and featured FLT3 mutations, frequent IKZF1 deletions, and a higher overall burden of karyotypic gains and losses.

  • 4

    CEBPE rearrangements occurred only in Cluster A, whereas CEBPD rearrangements occurred exclusively in Cluster B.

  • 5

    The clusters showed different B-cell developmental signatures, with pre-B I enrichment in Cluster B and pre-B II Small or Immature B-cell enrichment in Cluster A.

Original Source(s)

CEBP-altered B-ALL: Two transcriptomic profiles across the age spectrum

  • by Jacqueline A. Rehn, Ashlee J. Thomson-Roberts, David T. Yeung, Deborah L. White, Elyse C. Page

  • October 17, 2026

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