Case Report: Decade-delayed thyroid metastasis with cervical lymph node involvement from clear cell renal cell carcinoma: diagnostic pitfalls of cytologic-radiologic discordance - Takeaways - MDSpire

Case Report: Decade-delayed thyroid metastasis with cervical lymph node involvement from clear cell renal cell carcinoma: diagnostic pitfalls of cytologic-radiologic discordance

  • By

  • Seok-Kyung Kang

  • Miri Ryu

  • Seungju Lee

  • June 12, 2026

  • 0 min

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  • 1

    Clear cell renal cell carcinoma (RCC) can metastasize to the thyroid many years after nephrectomy, posing diagnostic challenges.

  • 2

    Distinguishing metastatic RCC from primary thyroid neoplasms is difficult based on ultrasound and fine-needle aspiration cytology alone.

  • 3

    Histopathology and immunohistochemistry are essential for confirming metastatic RCC, showing specific marker positivity and negativity.

  • 4

    In patients with a history of RCC, new thyroid nodules should raise suspicion for metastasis, even years post-treatment.

  • 5

    A multidisciplinary approach is crucial for managing isolated metastatic disease, integrating surgical resection with systemic therapy.

Original Source(s)

Case Report: Decade-delayed thyroid metastasis with cervical lymph node involvement from clear cell renal cell carcinoma: diagnostic pitfalls of cytologic-radiologic discordance

  • by Seok-Kyung Kang, Miri Ryu, Seungju Lee

  • June 12, 2026

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