Case Report: Treatment of trachyonychia in children with crisaborole: a retrospective case series - Takeaways - MDSpire

Case Report: Treatment of trachyonychia in children with crisaborole: a retrospective case series

  • By

  • Xue Wang

  • Keying Li

  • Yuanxiang Liu

  • Rui He

  • Yujuan Sun

  • Zigang Xu

  • Bin Zhang

  • July 15, 2026

Share

  • 1

    Trachyonychia is a chronic nail disorder in children aged 3–12, characterized by nail plate roughness and longitudinal ridging.

  • 2

    Crisaborole, a nonsteroidal PDE4 inhibitor, was applied topically to 13 children diagnosed with trachyonychia in a retrospective study.

  • 3

    At 6 weeks, 82.1% of nails showed significant improvement, with 43.2% achieving complete remission.

  • 4

    At 12 weeks, 48.5% of nails maintained complete remission, and no severe adverse events were reported.

  • 5

    The study suggests that crisaborole is effective and well-tolerated for treating pediatric trachyonychia.

Original Source(s)

Case Report: Treatment of trachyonychia in children with crisaborole: a retrospective case series

  • by Xue Wang, Keying Li, Yuanxiang Liu, Rui He, Yujuan Sun, Zigang Xu, Bin Zhang

  • July 15, 2026

Related Content

AD Not Linked to Early CV Risk Markers

Repeated assessments from childhood to early adulthood did not identify consistent cardiometabolic risk patterns by disease activity or severity.

Editorial: Rethinking infection in pediatric atopic dermatitis: from microbial dysbiosis to precision prevention

AI Discharge Summaries Show Low Harm Risk

Most reviewed summaries were rated as posing no harm risk, although omissions remained common.