Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry - Takeaways - MDSpire

Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry

  • By

  • Anqi Luo

  • Sujani Bandela

  • Gretchel Gealogo-Brown

  • Mark P. Goldberg

  • Andrew Slusher

  • Reza Behrouz

  • Alibay Jafarli

  • Siddarth Prasad

  • DaiWai Olson

  • Maria Denbow

  • Mehari Gebreyohanns

  • Asmiet Techan

  • Chethan P. Venkatasubba Rao

  • Jane A. Anderson

  • Barbara Kimmel

  • Anette Ovalle

  • Michele Patterson

  • Sean I. Savitz

  • Salvador Cruz-Flores

  • Steven Warach

  • Lee Birnbaum

  • May 4, 2026

  • 0 min

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  • 1

    Tenecteplase (TNK) administration significantly reduces door-to-puncture (DTP) times compared to alteplase (ALT) in patients undergoing thrombectomy.

  • 2

    The average DTP time for TNK patients was 80 minutes, while ALT patients had a DTP time of 101.5 minutes, showing a statistically significant difference.

  • 3

    Needle-to-puncture times were also shorter for TNK at 39 minutes compared to 55 minutes for ALT, contributing to the overall reduced DTP time.

  • 4

    Both TNK and ALT groups exhibited similar favorable outcomes at discharge, indicating comparable efficacy in clinical results.

  • 5

    The study supports transitioning to TNK as a preferable option for large vessel occlusion stroke patients requiring intravenous thrombolysis and mechanical thrombectomy.

Original Source(s)

Transition to tenecteplase is associated with shorter door-to-puncture times: a retrospective study from the Lone Star Stroke consortium TNK registry

  • by Anqi Luo, Sujani Bandela, Gretchel Gealogo-Brown, Mark P. Goldberg, Andrew Slusher, Reza Behrouz, Alibay Jafarli, Siddarth Prasad, DaiWai Olson, Maria Denbow, Mehari Gebreyohanns, Asmiet Techan, Chethan P. Venkatasubba Rao, Jane A. Anderson, Barbara Kimmel, Anette Ovalle, Michele Patterson, Sean I. Savitz, Salvador Cruz-Flores, Steven Warach, Lee Birnbaum

  • May 4, 2026

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