Menopause and ageing in women with multiple sclerosis - Takeaways - MDSpire
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The Impact of Menopause and Ageing on Women Diagnosed with Multiple Sclerosis

  • By

  • Cecilia Smith Simonsen

  • Elisabeth Gulowsen Celius

  • June 9, 2026

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  • 1

    Menopause does not appear to independently influence relapse activity or MRI-defined inflammation in women with multiple sclerosis.

  • 2

    Recent studies indicate menopause does not significantly affect Expanded Disability Status Scale progression when accounting for age.

  • 3

    Symptom burden often worsens during midlife due to hormonal changes, comorbidities, and ageing, complicating clinical management.

  • 4

    Menopausal hormone therapy may alleviate symptoms but its impact on multiple sclerosis disease progression remains uncertain.

  • 5

    Menopause should be viewed as part of broader biological ageing rather than a distinct inflection point in multiple sclerosis.

Original Source(s)

Menopause and ageing in women with multiple sclerosis

  • by Cecilia Smith Simonsen, Elisabeth Gulowsen Celius

  • June 9, 2026

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