Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition - Takeaways - MDSpire

Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition

  • By

  • Tomaž Podnar

  • Ralf Geiger

  • Ira Winkler

  • Elke Griesmaier

  • Susanne Sprung

  • Ursula Kiechl-Kohlendorfer

  • June 5, 2026

  • 0 min

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  • 1

    Isolated prenatal foramen ovale closure or restriction is a rare condition diagnosed postnatally, affecting 0.3% of admitted neonates.

  • 2

    Neonates with this condition often present with cyanosis, respiratory distress, and impaired left ventricular function, alongside preserved right ventricular function.

  • 3

    Management typically includes prostaglandin infusion, inotropic support, and pulmonary arterial hypertension therapy to stabilize the neonates.

  • 4

    Most neonates experience normalization of left ventricular function within days, with a transition to a left-to-right ductus arteriosus shunt.

  • 5

    Early recognition and hemodynamic support can lead to full recovery in the majority of cases, despite some experiencing significant complications.

Original Source(s)

Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition

  • by Tomaž Podnar, Ralf Geiger, Ira Winkler, Elke Griesmaier, Susanne Sprung, Ursula Kiechl-Kohlendorfer

  • June 5, 2026

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