Interaction of CD99 and its ligands regulates immunoregulatory pathways in NK cells - Takeaways - MDSpire

Interaction of CD99 and its ligands regulates immunoregulatory pathways in NK cells

  • By

  • Myint Myat Thu

  • Nuchjira Takheaw

  • Witida Laopajon

  • Watchara Kasinrerk

  • Supansa Pata

  • June 4, 2026

  • 0 min

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  • 1

    CD99 is a transmembrane glycoprotein that modulates NK cell receptor expression and activation states during immune responses.

  • 2

    Engagement of CD99 with its ligands leads to downregulation of natural cytotoxicity receptors (NCRs) in NK cells.

  • 3

    The study found differential effects of CD99 on NK cells depending on whether they were in peripheral blood mononuclear cells or purified cultures.

  • 4

    Despite changes in receptor expression, CD99 engagement did not significantly alter cytokine production in NK cells.

  • 5

    These findings highlight the context-dependent role of CD99 in shaping NK cell activation and phenotypic diversity.

Original Source(s)

Interaction of CD99 and its ligands regulates immunoregulatory pathways in NK cells

  • by Myint Myat Thu, Nuchjira Takheaw, Witida Laopajon, Watchara Kasinrerk, Supansa Pata

  • June 4, 2026

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