A Framework for EEG Source Imaging Utilizing Network Analysis to Noninvasively Identify Epileptogenic Zones in Patients with MRI-Negative Focal Drug-Resistant Epilepsy - Takeaways - MDSpire

A Framework for EEG Source Imaging Utilizing Network Analysis to Noninvasively Identify Epileptogenic Zones in Patients with MRI-Negative Focal Drug-Resistant Epilepsy

  • By

  • Shicun Huang

  • Xiaowei Hu

  • Yiqing Wang

  • Wei Gao

  • Qi Fang

  • January 15, 2026

  • 0 min

Share

  • 1

    Approximately one-third of epilepsy patients develop drug-resistant epilepsy (DRE), necessitating alternative treatment strategies.

  • 2

    Surgical resection of the epileptogenic zone (EZ) is effective in 60-80% of focal DRE cases, but outcomes are poorer in MRI-negative patients.

  • 3

    Electroencephalographic source imaging (ESI) is a promising non-invasive method for localizing the EZ in MRI-negative epilepsy.

  • 4

    Integrating functional connectivity analysis with ESI enhances the identification of critical network nodes in epileptogenic networks.

  • 5

    The proposed multidimensional ESI framework aims to improve non-invasive EZ localization and support presurgical evaluations in MRI-negative DRE patients.

Original Source(s)

A Framework for EEG Source Imaging Utilizing Network Analysis to Noninvasively Identify Epileptogenic Zones in Patients with MRI-Negative Focal Drug-Resistant Epilepsy

  • by Shicun Huang, Xiaowei Hu, Yiqing Wang, Wei Gao, Qi Fang

  • January 15, 2026

Related Content

Clinical Characteristics of Epilepsy Linked to SYNGAP1 Gene Variants: Analysis of Six Cases and Review of Existing Literature

Defining the target for hemifacial spasm –regarding microvascular decompression

Middle-aged predominance and diagnostic delays in anti-LGI1 encephalitis: the role of antibody testing