The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis

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The CALLY index is a composite biomarker that integrates inflammation, nutrition, and immunity, but its prognostic value in sepsis is inconsistent.
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This meta-analysis included six studies with 3,848 septic patients, revealing no significant difference in CALLY index between survivors and non-survivors.
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Subgroup analyses indicated that a higher CALLY index correlated with survival in Chinese cohorts but with mortality in a Turkish cohort.
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Multivariate analysis demonstrated a significant association between a higher CALLY index and lower mortality risk, with an HR of 0.48.
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The CALLY index shows potential as a low-cost biomarker for sepsis, but its variable mortality association necessitates further validation in diverse populations.

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