The FDA approved icotrokinra, an oral interleukin-23 receptor antagonist, for moderate-to-severe plaque psoriasis in patients aged 12 and older.
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Icotrokinra offers a new oral treatment option, potentially replacing injectable biologics for patients not responding to topical therapies.
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In clinical trials, approximately 70% of patients achieved clear or nearly clear skin, with 55% showing a 90% reduction in disease severity by week 16.
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Adverse events were similar to placebo, with common side effects including headache, nausea, cough, fatigue, and fungal infection.
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Plaque psoriasis affects over 8 million people in the US, impacting their physical comfort and quality of life, especially in sensitive areas.
