Castration-induced nigrostriatal deficits are linked to reduced TrkB and loss of mature spines in the dorsal striatum

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Castration in male mice leads to reduced dopamine neuron survival and impaired motor function, mimicking Parkinsonian symptoms.
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Androgen deprivation results in decreased mushroom spine density and increased immature spine classes in striatal neurons.
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Reduced levels of TrkB protein are associated with impaired BDNF signaling, affecting neuronal health and synaptic maturation.
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Testosterone replacement therapy preserves dopamine neurons and normalizes motor behavior while preventing spine loss.
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The study suggests that androgen signaling is crucial for maintaining nigrostriatal integrity and synaptic stability.

Frontiers In Endocrinology

by Gerald J. Donahue, James A. Lundari, Patrick W. Kane, Samantha M. Matamorose-Patrick, Julia E. Klotz, Nicholas L. Carr, Stephen C. Kudriavetz, Joe C. Brague
June 3, 2026

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