Case Report: Lenalidomide as a novel maintenance therapy for metastatic follicular dendritic cell sarcoma

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Follicular dendritic cell sarcoma (FDCS) is a rare malignancy with inconsistent treatment outcomes and a high recurrence rate.
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Conventional therapies for metastatic FDCS, including chemotherapy, often provide only transient disease control.
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Lenalidomide has been used as a novel maintenance therapy for FDCS, showing promise in achieving sustained remission.
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The patient in the case study experienced nearly seven years of disease stabilization with lenalidomide after chemotherapy.
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This case suggests lenalidomide may be a beneficial option for patients with metastatic FDCS when standard treatments fail.

Frontiers In Oncology

by Saarang Kashyap, Esha Sankhala, Jordan Ziegler, Rebecca Godin, Ivan Huang, James Heeter, Spencer Rosant, Kamlesh K. Sankhala
May 14, 2026

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