Targeting macrophage metabolism: mechanisms, cellular crosstalk and implications in obesity-associated metabolic diseases

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Obesity is a chronic metabolic disorder linked to systemic inflammation and is a significant risk factor for various metabolic diseases.
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Macrophages play a crucial role in maintaining tissue homeostasis and are involved in the progression of obesity-related metabolic disorders.
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The concept of immunometabolism describes the interplay between immune cell activation and systemic metabolic homeostasis during obesity.
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Macrophages exhibit phenotypic plasticity, polarizing into M1 or M2 subsets based on local environmental cues, influencing their functions.
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Understanding macrophage metabolism and interactions with metabolic tissues may lead to novel therapeutic strategies for obesity-related disorders.

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