Management of Iron Overload in Infants and Toddlers With Diamond–Blackfan Anemia Syndrome: A French–Italian Study - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Approaches to Managing Iron Overload in Young Children With Diamond–Blackfan Anemia Syndrome: Insights from a French–Italian Investigation

  • By

  • Francesca Torchio

  • Baptiste Lecalvez

  • Emanuela Garelli

  • Coralie Mallebranche

  • Adriana Carando

  • Marie-Pierre Castex

  • Nathalie Garnier

  • Marco Zecca

  • Nathalie Aladjidi

  • Elisa Bertoni

  • Arthur Sterin

  • Maria Licciardello

  • Anne Sirvent

  • Antonella Sau

  • Isabelle Marie

  • Benedicte Bruno

  • Lydie M. Da Costa

  • Franca Fagioli

  • Paola Quarello

  • Thierry Leblanc

  • May 11, 2026

Share

  • 1

    Diamond–Blackfan Anemia Syndrome (DBAS) is a rare disorder affecting 5–10 cases per million live births, characterized by pure red cell aplasia and cancer predisposition.

  • 2

    Approximately 90% of DBAS patients require regular blood transfusions within their first year, leading to chronic iron overload.

  • 3

    Iron chelation therapy is critical for managing iron overload in DBAS, yet no specific guidelines exist for initiating treatment in infants and toddlers.

  • 4

    Three chelating agents are available for DBAS: deferoxamine, deferasirox, and deferiprone, each with specific limitations for use in young children.

  • 5

    A retrospective study was conducted to evaluate iron chelation practices in DBAS patients under three years of age from French and Italian cohorts.

Original Source(s)

Management of Iron Overload in Infants and Toddlers With Diamond–Blackfan Anemia Syndrome: A French–Italian Study

  • by Francesca Torchio, Baptiste Lecalvez, Emanuela Garelli, Coralie Mallebranche, Adriana Carando, Marie-Pierre Castex, Nathalie Garnier, Marco Zecca, Nathalie Aladjidi, Elisa Bertoni, Arthur Sterin, Maria Licciardello, Anne Sirvent, Antonella Sau, Isabelle Marie, Benedicte Bruno, Lydie M. Da Costa, Franca Fagioli, Paola Quarello, Thierry Leblanc

  • May 11, 2026

Related Content

Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients

Scanning New Horizons (in Digital Pathology)

How biomedical imaging technician Andrew Mullen championed the implementation of digital pathology across a large children's hospital

  • April 3, 2026

  • 5 min
External validation of an artificial intelligence tool for fracture detection in children with osteogenesis imperfecta: a multireader study