In a cohort of 1,266 middle-aged adults, investigators assessed cannabis exposure over 35 years and sleep outcomes during 2020 to 2022.
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Each additional cannabis-year was associated with lower sleep percentage, greater sleep fragmentation, and more wakefulness after sleep onset on actigraphy.
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Recent cannabis use was associated with poorer objective sleep measures and longer sleep duration than never use; former use was not significantly associated with objective sleep.
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Neither recent nor cumulative cannabis exposure was associated with self-reported sleep quality.
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The observational study could not establish causation, and the authors called for longitudinal, mechanistic, and randomized studies with long-term follow-up and objective sleep assessments.
