Radiomic features from intratumoral and peritumoral regions on portal venous phase CT for multicenter prediction of TP53 mutation in pancreatic cancer - Takeaways - MDSpire

Radiomic features from intratumoral and peritumoral regions on portal venous phase CT for multicenter prediction of TP53 mutation in pancreatic cancer

  • By

  • Shuyu Zhang

  • Xin Song

  • Kang Fu

  • Jie Liu

  • June 10, 2026

  • 0 min

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  • 1

    TP53 mutations occur in 50–70% of pancreatic ductal adenocarcinomas, influencing tumor aggressiveness and treatment response.

  • 2

    A multicenter study analyzed 216 PDAC patients using portal-venous phase CT to predict TP53 mutations non-invasively.

  • 3

    The Intra-Peri Model combining intratumoral and peritumoral features achieved the highest performance with an AUC of 0.893.

  • 4

    SHAP analysis identified key predictors of TP53 mutation, including intratumoral gray-level skewness and peritumoral texture correlation.

  • 5

    The study supports integrating radiomics for accurate TP53 status prediction in PDAC, aiding individualized treatment planning.

Original Source(s)

Radiomic features from intratumoral and peritumoral regions on portal venous phase CT for multicenter prediction of TP53 mutation in pancreatic cancer

  • by Shuyu Zhang, Xin Song, Kang Fu, Jie Liu

  • June 10, 2026

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