Connectome-based mapping of gray matter abnormalities in hepatic encephalopathy - Takeaways - MDSpire

Connectome-based mapping of gray matter abnormalities in hepatic encephalopathy

  • By

  • Li Chen

  • Lei Xia

  • Yaling Chen

  • Chengkun Hong

  • Minghui Mao

  • Xiaoyang Wang

  • Lili Zhou

  • July 10, 2026

  • 0 min

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  • 1

    Hepatic encephalopathy (HE) is associated with widespread gray matter abnormalities affecting multiple brain regions.

  • 2

    A study involving 45 HE patients and 45 healthy controls utilized high-resolution T1-weighted MRI to assess gray matter changes.

  • 3

    Gray matter abnormalities in HE patients did not significantly align with normative functional or structural brain hubs.

  • 4

    Structural neighborhood abnormalities correlated positively with cortical changes, while functional neighborhoods did not.

  • 5

    Key disease epicenters in HE were identified in the left inferior frontal gyrus, orbitofrontal cortex, and striatum.

Original Source(s)

Connectome-based mapping of gray matter abnormalities in hepatic encephalopathy

  • by Li Chen, Lei Xia, Yaling Chen, Chengkun Hong, Minghui Mao, Xiaoyang Wang, Lili Zhou

  • July 10, 2026

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