Association between SIRT1 gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis - Takeaways - MDSpire

Association between SIRT1 gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis

  • By

  • Di An

  • Huan Wu

  • Shujin Wu

  • Yuanpeng Deng

  • Shuangshuang Yang

  • Wansheng Wang

  • Yi Xiang

  • Xingde Liu

  • July 3, 2026

  • 0 min

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  • 1

    This systematic review and meta-analysis evaluated the association between SIRT1 gene polymorphisms and coronary artery disease (CAD) risk.

  • 2

    Nine studies were included, with SIRT1 polymorphisms rs7069102, rs7895833, and rs4746720 analyzed for their association with CAD.

  • 3

    Rs7069102 showed no significant association with CAD overall, but indicated a consistent risk effect in the CAD subgroup.

  • 4

    Rs7895833 was associated with increased CAD susceptibility under the recessive model, while rs4746720 showed significant associations under dominant and heterozygote models.

  • 5

    The findings suggest variability in associations by SNP locus, genetic model, and population, highlighting the need for further studies with clinical confounder adjustments.

Original Source(s)

Association between SIRT1 gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis

  • by Di An, Huan Wu, Shujin Wu, Yuanpeng Deng, Shuangshuang Yang, Wansheng Wang, Yi Xiang, Xingde Liu

  • July 3, 2026

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