Necrotizing soft tissue infections: a surgical narrative review - Takeaways - MDSpire

Necrotizing soft tissue infections: a surgical narrative review

  • By

  • Silvia Tedesco

  • Marta Di Grezia

  • Giuseppe Tropeano

  • Gaia Altieri

  • Giuseppe Brisinda

  • April 28, 2025

  • 0 min

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  • 1

    Necrotizing soft tissue infections (NSTIs) cause rapid tissue necrosis and can lead to significant morbidity and mortality if not treated promptly.

  • 2

    Diagnosis of NSTIs is challenging, as there are no definitive laboratory or radiological tests; surgical intervention is required for confirmation.

  • 3

    Risk factors for NSTIs include diabetes, obesity, immunosuppression, and local trauma, but they can also affect healthy individuals.

  • 4

    NSTIs can be classified by anatomical location and depth of infection, but these classifications do not significantly impact treatment approaches.

  • 5

    Early recognition of NSTIs is critical, as misdiagnosis occurs in 71% of cases, leading to delays in treatment and increased mortality risk.

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