Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer’s disease

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Medium-chain triglycerides (MCT) supplementation shows potential therapeutic benefits for Alzheimer's disease by enhancing cognitive function.
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MCT supplementation improves spatial learning and memory in Alzheimer's disease mouse models without elevating circulating ketone levels.
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MCT enhances peripheral insulin response in Alzheimer's disease mice, contrasting with ketogenic diets that increase metabolic vulnerabilities.
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Both MCT and ketogenic diets partially reverse liver metabolic abnormalities in Alzheimer's disease mice, but through distinct mechanisms.
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MCT supplementation downregulates cholesterol-related gene expression, while ketogenic diets trigger proinflammatory gene expression.

Brain

by Paule E H M’Bra, Laura K Hamilton, Gaël Moquin-Beaudry, Chenicka L Mangahas, Federico Pratesi, Anne Castonguay, Sophia Mailloux, Manon Galoppin, Jessica Avila Lopez, Megan Bernier, Marta Turri, Marian Mayhue, Anne Aumont, Martine Tetreault, Stephen C Cunnane, Karl J L Fernandes
August 6, 2025

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