POEMS syndrome with multiple ganglioside/paraneoplastic antibodies misdiagnosed as CIDP: a case report

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POEMS syndrome is a rare disorder characterized by polyneuropathy, organomegaly, endocrinopathy, M-protein secretion, and skin changes.
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CIDP is an immune-mediated condition affecting peripheral nerve myelin, lacking systemic involvement and hematological markers seen in POEMS.
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The case study highlights a 57-year-old male misdiagnosed with CIDP, presenting with lower limb paresthesia and progressive sensory loss.
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Diagnosis of POEMS syndrome was clarified through clinical evaluation, specialized laboratory findings, and histopathological analysis.
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The study emphasizes the need for clinical vigilance to accurately distinguish between POEMS syndrome and CIDP due to their overlapping symptoms.

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