Creation and assessment of a predictive model utilizing choroid plexus imaging from brain MRI for evaluating anti-TNF-α treatment responses in Crohn’s disease - Takeaways - MDSpire

Creation and assessment of a predictive model utilizing choroid plexus imaging from brain MRI for evaluating anti-TNF-α treatment responses in Crohn’s disease

  • By

  • Mengting Huang

  • Shuo Huang

  • Qinyue Luo

  • Yuting Zheng

  • Hanting Li

  • Ping Han

  • Liangru Zhu

  • Heshui Shi

  • March 6, 2026

  • 0 min

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  • 1

    Crohn's disease is a chronic inflammatory bowel disease characterized by gastrointestinal and systemic symptoms.

  • 2

    Anti-TNF-α therapies, such as infliximab and adalimumab, are crucial for treating moderate to severe Crohn's disease.

  • 3

    Response to anti-TNF-α therapy varies, with 10-20% of patients showing primary non-response and 23-46% experiencing secondary loss of response.

  • 4

    The choroid plexus may serve as a neuro-immune interface, linking gut inflammation with central nervous system alterations.

  • 5

    This study aims to develop a predictive model using choroid plexus imaging to assess treatment responses to anti-TNF-α in Crohn's disease.

Original Source(s)

Creation and assessment of a predictive model utilizing choroid plexus imaging from brain MRI for evaluating anti-TNF-α treatment responses in Crohn’s disease

  • by Mengting Huang, Shuo Huang, Qinyue Luo, Yuting Zheng, Hanting Li, Ping Han, Liangru Zhu, Heshui Shi

  • March 6, 2026

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