A network analysis of symptom clusters and core symptoms in colorectal cancer patients undergoing postoperative chemotherapy - Takeaways - MDSpire

A network analysis of symptom clusters and core symptoms in colorectal cancer patients undergoing postoperative chemotherapy

  • By

  • Bingbing Xiao

  • Wendan Jing

  • Jiayi Wang

  • Jing Zhao

  • Tingting Tan

  • Xiangzhen Liu

  • Qijun Lv

  • Hongyan Kou

  • May 6, 2026

  • 0 min

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  • 1

    The study identified three symptom clusters in colorectal cancer patients post-surgery and chemotherapy: gastrointestinal-psychological, neurotoxicity, and CRC-specific.

  • 2

    Network analysis revealed that 'Poor appetite' was the most influential symptom, while 'Nausea' exhibited the highest centrality metrics.

  • 3

    Fatigue was found to have the highest incidence rate among symptoms, affecting 89.6% of the patients surveyed.

  • 4

    The research emphasizes the importance of prioritizing management of poor appetite and nausea to enhance patient care and quality of life.

  • 5

    This study contributes to understanding symptom dynamics after six cycles of chemotherapy, addressing a gap in existing colorectal cancer research.

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