Staged antibiotic-loaded cement-based reconstruction versus flap-based reconstruction for complex diabetic foot defects in patients with osteoporosis: a retrospective cohort study - Takeaways - MDSpire

Staged antibiotic-loaded cement-based reconstruction versus flap-based reconstruction for complex diabetic foot defects in patients with osteoporosis: a retrospective cohort study

  • By

  • Hanlin Zhang

  • Desheng Chen

  • Qiang Song

  • Fan Gong

  • Peiling Li

  • Yu Li

  • Le Fei

  • Yanchuan Yang

  • Anyang Yu

  • May 20, 2026

  • 0 min

Share

  • 1

    The study compared the efficacy and safety of antibiotic-loaded bone cement with negative pressure therapy and flap surgery for diabetic foot ulcers.

  • 2

    Operative time and blood loss were significantly lower in the AB-NPWT group compared to the flap surgery group.

  • 3

    At 12 months, complete wound healing and limb salvage rates were similar between the two treatment groups.

  • 4

    Complication rates were comparable, but the profiles of complications differed between the AB-NPWT and flap surgery groups.

  • 5

    The findings suggest individualized treatment selection based on patient characteristics, with no significant differences in main outcomes.

Original Source(s)

Staged antibiotic-loaded cement-based reconstruction versus flap-based reconstruction for complex diabetic foot defects in patients with osteoporosis: a retrospective cohort study

  • by Hanlin Zhang, Desheng Chen, Qiang Song, Fan Gong, Peiling Li, Yu Li, Le Fei, Yanchuan Yang, Anyang Yu

  • May 20, 2026

Related Content

Side Effects: Salt, Steroids, and Second Brains

So get this: sodium may track with memory decline (in men), steroids might not be “immunosuppressive” in the ICU, and second pregnancies reshape the brain differently than first. Same theme: biology is less binary than we teach it.

Retrospective study of mechanical complications after cephalomedullary nail implantation from 2019 to 2024 following per-, sub- or intertrochanteric femur fractures

Weighted Vest in Obesity Trial

Daily standing and stepping time appeared to modify hip bone responses during dietary weight loss in a randomized trial