Evaluation of Risk Factors for Failed Seroconversion in the Management of Potential Lyssavirus Exposures - Takeaways - MDSpire

Evaluation of Risk Factors for Failed Seroconversion in the Management of Potential Lyssavirus Exposures

  • By

  • James Harris

  • Kate Alexander

  • Penny Hutchinson

  • Deborah Judd

  • Bonnie Macfarlane

  • Catherine Quagliotto

  • Vicki Slinko

  • James Smith

  • Nicolas Smoll

  • Mark Stickley

  • Alexandra Uren

  • Megan Young

  • January 15, 2026

  • 0 min

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  • 1

    Improper vaccine administration increases the risk of nontherapeutic serology after rabies postexposure prophylaxis.

  • 2

    Administering rabies vaccine in the wrong site has a relative risk of 10.8 for failed seroconversion.

  • 3

    Giving a rabies vaccine into the same arm within 72 hours of rabies immunoglobulin raises the risk of nontherapeutic serology.

  • 4

    Individuals aged 65 and older are at a higher risk of failed seroconversion after rabies vaccination.

  • 5

    In cases of administration errors, it is recommended to invalidate the dose and repeat it without serology.

Original Source(s)

Evaluation of Risk Factors for Failed Seroconversion in the Management of Potential Lyssavirus Exposures

  • by James Harris, Kate Alexander, Penny Hutchinson, Deborah Judd, Bonnie Macfarlane, Catherine Quagliotto, Vicki Slinko, James Smith, Nicolas Smoll, Mark Stickley, Alexandra Uren, Megan Young

  • January 15, 2026

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