Case Report: Synchronous minute intramucosal Epstein–Barr virus-associated gastric cancer revealed after short-term Helicobacter pylori eradication - Takeaways - MDSpire

Case Report: Synchronous minute intramucosal Epstein–Barr virus-associated gastric cancer revealed after short-term Helicobacter pylori eradication

  • By

  • Dongqi Wu

  • Quan Luo

  • Weiming Wang

  • Xueman Wang

  • June 30, 2026

  • 0 min

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  • 1

    Epstein–Barr virus-associated gastric cancer (EBVaGC) accounts for approximately 8.7% of gastric cancers and predominantly affects males.

  • 2

    The case involved a 56-year-old patient diagnosed with gastric adenocarcinoma, revealing two distinct superficial depressed lesions post-Helicobacter pylori treatment.

  • 3

    Endoscopic submucosal dissection (ESD) confirmed two independent foci of intramucosal EBVaGC, achieving curative resection without lymphovascular invasion.

  • 4

    Active Helicobacter pylori infection can obscure minute neoplastic lesions, complicating their detection and assessment during endoscopy.

  • 5

    Short-term Helicobacter pylori eradication may improve the detection of gastric lesions and delineation of margins, warranting further validation in larger studies.

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