Cytomegalovirus DNA Presence in Southern Chinese Patients with Anti-Melanoma Differentiation-Associated Gene 5 Positive Dermatomyositis - Takeaways - MDSpire
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Cytomegalovirus DNA Presence in Southern Chinese Patients with Anti-Melanoma Differentiation-Associated Gene 5 Positive Dermatomyositis

  • By

  • Yuanyuan Niu

  • Huijuan Hu

  • Yuting Gu

  • Kai Sun

  • Qian Qiu

  • Di Fu

  • Haonan Chen

  • Liuqin Liang

  • Shanhui Ye

  • Youjun Xiao

  • Hanshi Xu

  • February 9, 2026

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  • 1

    Cytomegalovirus (CMV) is a prevalent opportunistic infection in immunocompromised patients, including those with autoimmune diseases.

  • 2

    Anti-MDA5-positive dermatomyositis (DM) is a severe subtype of idiopathic inflammatory myopathy, particularly common in East Asia.

  • 3

    The study assessed the prevalence of CMV DNAemia in patients with anti-MDA5-positive DM and its impact on 6-month mortality.

  • 4

    Risk factors for CMV infection in these patients include older age, lymphocytopenia, and high doses of glucocorticoids.

  • 5

    The study utilized quantitative nucleic acid amplification testing (QNAT) to detect active CMV replication in blood samples.

Original Source(s)

Cytomegalovirus DNA Presence in Southern Chinese Patients with Anti-Melanoma Differentiation-Associated Gene 5 Positive Dermatomyositis

  • by Yuanyuan Niu, Huijuan Hu, Yuting Gu, Kai Sun, Qian Qiu, Di Fu, Haonan Chen, Liuqin Liang, Shanhui Ye, Youjun Xiao, Hanshi Xu

  • February 9, 2026

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