Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus - Takeaways - MDSpire

Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus

  • By

  • Ana Laura Hernández-Ledesma

  • Evelia Lorena Coss-Navarrete

  • Sofia Salazar-Magaña

  • Diego Ramírez-Espinosa

  • Lizbet Tinajero-Nieto

  • Estefania Torres-Valdez

  • Angélica H. Peña-Ayala

  • Guillermo Félix-Rodriguez

  • Gabriel Frontana-Vázquez

  • Jair Santiago García Sotelo

  • Morgane Thomas-Chollier

  • Gosia Trynka

  • Florencia Rosetti

  • Selene L. Fernandez-Valverde

  • María Gutiérrez-Arcelus

  • Deshiré Alpízar-Rodríguez

  • Alejandra Medina-Rivera

  • June 2, 2026

  • 0 min

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  • 1

    Dendritic cells (DCs) play a crucial role in immune tolerance, and their dysfunction contributes to systemic lupus erythematosus (SLE).

  • 2

    Interferon stimulated genes (ISGs) are significantly enriched in monocytes from SLE patients, indicating their importance in disease pathology.

  • 3

    In SLE-derived tolerogenic DCs, lipid metabolism pathways are altered, suggesting impaired production of pro-resolving lipid mediators.

  • 4

    Diminished IL10RA expression and dysregulated IRF4 activity in SLE monocyte-derived DCs indicate defects in IL-10 mediated tolerogenic differentiation.

  • 5

    The study highlights transcriptional rewiring and impaired signaling pathways in DCs that compromise their ability to maintain immune tolerance in SLE.

Original Source(s)

Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus

  • by Ana Laura Hernández-Ledesma, Evelia Lorena Coss-Navarrete, Sofia Salazar-Magaña, Diego Ramírez-Espinosa, Lizbet Tinajero-Nieto, Estefania Torres-Valdez, Angélica H. Peña-Ayala, Guillermo Félix-Rodriguez, Gabriel Frontana-Vázquez, Jair Santiago García Sotelo, Morgane Thomas-Chollier, Gosia Trynka, Florencia Rosetti, Selene L. Fernandez-Valverde, María Gutiérrez-Arcelus, Deshiré Alpízar-Rodríguez, Alejandra Medina-Rivera

  • June 2, 2026

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