Roswell Park Offering CAR T Trial for Autoimmune Conditions - Takeaways - MDSpire

Roswell Park Offering CAR T Trial for Autoimmune Conditions

While most CAR T-cell therapies and clinical trials are directed at cancers, a new phase 1 trial at Roswell Park Comprehensive Cancer Center is open and recruiting patients with a variety of autoimmune conditions.

  • December 12, 2025

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    Roswell Park Comprehensive Cancer Center is conducting a phase 1 trial for CAR T-cell therapy targeting autoimmune conditions.

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    The trial is led by Dr. Alicia Lieberman and is recruiting patients with systemic lupus, lupus nephritis, or systemic sclerosis.

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    The goal of the trial is to achieve a deep immune reset for better long-term control of refractory autoimmune conditions.

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    Patients will receive chemotherapy followed by an infusion of novel CD20-directed CAR T-cell therapy.

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    This trial is unique in the U.S. for using gamma-delta T-cells, which are effective in targeting inflamed tissues.

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Roswell Park Offering CAR T Trial for Autoimmune Conditions

  • December 12, 2025

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