Neonatal CD19+B220lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation - Takeaways - MDSpire

Neonatal CD19+B220lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation

  • By

  • Carolina Ruiz-Sánchez

  • Isabel Cortegano

  • Mercedes Rodríguez

  • Rodrigo Sanchez-Tarjuelo

  • Alejandro Arrabal

  • M. Carmen Prado

  • Mario Alia

  • M.Pilar Jiménez

  • Victor Manuel Lopez Molina

  • Sara Monzón

  • Victoria López-Alonso

  • Belén de Andrés

  • Maria-Luisa Gaspar

  • June 19, 2026

  • 0 min

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  • 1

    Neonatal CD19+B220lo B cells in the lungs respond to microbiota through TLR2 and TLR4 activation.

  • 2

    Antibiotic treatment reduces the number of CD19+B220lo B cells and alters their VH immunoglobulin repertoire.

  • 3

    In vitro stimulation with TLR ligands induces proliferation and differentiation of neonatal B cells, generating CD138+ cells.

  • 4

    Lung cultures exhibit an inflammatory cytokine profile, while spleen cultures show a regulatory profile following TLR stimulation.

  • 5

    Findings indicate that neonatal lung and spleen CD19+B220lo cells can sense microbiota, promoting their activation and differentiation.

Original Source(s)

Neonatal CD19+B220lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation

  • by Carolina Ruiz-Sánchez, Isabel Cortegano, Mercedes Rodríguez, Rodrigo Sanchez-Tarjuelo, Alejandro Arrabal, M. Carmen Prado, Mario Alia, M.Pilar Jiménez, Victor Manuel Lopez Molina, Sara Monzón, Victoria López-Alonso, Belén de Andrés, Maria-Luisa Gaspar

  • June 19, 2026

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