Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials - Takeaways - MDSpire

Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials

  • By

  • Keye Chen

  • Yan Sun

  • Longkang Cui

  • Yuchen Zhu

  • Bingbing Zhang

  • Lianguo Wu

  • June 16, 2026

  • 0 min

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  • 1

    Probiotics may alleviate symptoms of knee osteoarthritis (KOA), particularly strains like Saccharomyces boulardii and LatiLactobacillus sakei LB-P12.

  • 2

    The study utilized a meta-analysis of randomized controlled trials to assess the efficacy and safety of probiotics in treating KOA.

  • 3

    Probiotics showed no significant adverse effects compared to placebo, indicating a favorable safety profile for long-term use.

  • 4

    Evidence supporting probiotics for KOA is limited due to small sample sizes and methodological inconsistencies in existing studies.

  • 5

    Further research is necessary to establish definitive conclusions regarding the clinical use of probiotics in KOA management.

Original Source(s)

Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials

  • by Keye Chen, Yan Sun, Longkang Cui, Yuchen Zhu, Bingbing Zhang, Lianguo Wu

  • June 16, 2026

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