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1
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by mesangial deposition of IgA-containing immune complexes.
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2
Dysregulated mucosal innate immune responses, particularly through TLR7 and TLR9, contribute to the pathogenesis of IgAN.
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3
Increased expression of TLR7 and TLR9 in mucosal tissues has been observed in patients with IgAN, indicating their role in immune activation.
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4
Galactose-deficient IgA1 (Gd-IgA1) production is promoted by TLR-mediated pathways, contributing to nephritogenic immune complex formation.
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5
Therapeutic advances targeting mucosal immunity, including hydroxychloroquine, highlight the clinical relevance of innate immune dysregulation in IgAN.
