Enhanced myelopoiesis and myeloid TREM1 upregulation link obesity with adverse outcomes after myocardial infarction - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Obesity-Related Myelopoiesis and TREM1 Activation Associated with Poor Prognosis Following Myocardial Infarction

  • By

  • Nadine Gladow

  • Ines Klohr

  • Xin Ding

  • Panagiota Arampatzi

  • Mugdha Srivastava

  • Jan Traub

  • Stefan Frantz

  • Gustavo Ramos

  • Ulrich Hofmann

  • September 11, 2026

Share

  • 1

    Obesity is linked to poorer left ventricular function following ST-elevation myocardial infarction (STEMI) compared to normal-weight patients.

  • 2

    High body mass index (BMI) correlates with increased inflammatory markers and circulating leukocyte counts after myocardial infarction.

  • 3

    Obesity-related metabolic disturbances induce myelopoietic changes in bone marrow, affecting myeloid cell responses post-myocardial infarction.

  • 4

    Obese mice exhibited enhanced myelopoiesis and increased TREM1 expression in the myocardium after myocardial infarction.

  • 5

    The study highlights a mechanistic link between obesity and impaired myocardial function following myocardial infarction.

Original Source(s)

Enhanced myelopoiesis and myeloid TREM1 upregulation link obesity with adverse outcomes after myocardial infarction

  • by Nadine Gladow, Ines Klohr, Xin Ding, Panagiota Arampatzi, Mugdha Srivastava, Jan Traub, Stefan Frantz, Gustavo Ramos, Ulrich Hofmann

  • September 11, 2026

Related Content

Low Cholesterol and Liver Risk—The Mechanism Matters

Patient-Clinician Racial and Language Concordance and Pharmacoequity

Comment on “Life’s essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants” and the inclusion of sleep in cancer focused guidelines