Effects of Tuberculosis and Its Treatment on Lung and Gut Microbiota: A Comprehensive Global Review and Meta-Analysis Using Amplicon-Based Metagenomics - Takeaways - MDSpire

Effects of Tuberculosis and Its Treatment on Lung and Gut Microbiota: A Comprehensive Global Review and Meta-Analysis Using Amplicon-Based Metagenomics

  • By

  • Monica Mbabazi

  • David Patrick Kateete

  • Faith Nakazzi

  • Joanitah Nabwire Wandera

  • Naume Mutesi

  • Moses Ocan

  • Irene Andia Biraro

  • Andrew Abaasa

  • William Evan Johnson

  • Bryan Wee

  • Adrian Muwonge

  • December 30, 2025

  • 0 min

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  • 1

    Tuberculosis (TB) is the leading infectious killer, causing approximately 1.25 million deaths in 2023.

  • 2

    Advances in metagenomic sequencing reveal the microbiome's significant role in TB pathogenesis and treatment outcomes.

  • 3

    Dysbiosis in TB patients is primarily influenced by immune responses in the lungs and anti-TB medication in the gut.

  • 4

    The study employs a mixed-methods approach to analyze microbiota differences between TB patients and healthy controls globally.

  • 5

    Understanding microbiota alterations in TB can inform the development of targeted interventions like prebiotics and probiotics.

Original Source(s)

Effects of Tuberculosis and Its Treatment on Lung and Gut Microbiota: A Comprehensive Global Review and Meta-Analysis Using Amplicon-Based Metagenomics

  • by Monica Mbabazi, David Patrick Kateete, Faith Nakazzi, Joanitah Nabwire Wandera, Naume Mutesi, Moses Ocan, Irene Andia Biraro, Andrew Abaasa, William Evan Johnson, Bryan Wee, Adrian Muwonge

  • December 30, 2025

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