Acetylcholine receptor antibody-positive myasthenia gravis and Kennedy’s disease overlap syndrome: a case report and literature review

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The study presents a rare case of overlap syndrome between acetylcholine receptor antibody-positive myasthenia gravis and Kennedy's disease.
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The patient, a 60-year-old man, exhibited fluctuating muscle weakness, diplopia, and dysphagia, with serological tests confirming AChR antibodies.
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Neurophysiological assessments and genetic testing confirmed the diagnosis of Kennedy's disease alongside myasthenia gravis.
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Literature review revealed only four previously reported cases of Kennedy's disease with myasthenic features, all AChR antibody-negative.
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The patient's treatment included pyridostigmine, prednisone, and efgartigimod alfa, leading to stabilization after multiple exacerbations.

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