G3BP1 methylation by PRMT5 facilitates its recruitment of TBK1 for IRF3 activation during host response to foreign ribonucleic acids - Takeaways - MDSpire

G3BP1 methylation by PRMT5 facilitates its recruitment of TBK1 for IRF3 activation during host response to foreign ribonucleic acids

  • By

  • Wen Song

  • Susana Soo-Yeon Kim

  • Candice Yam

  • Joey Teo

  • Jyue Yuan Lim

  • Xuezhi Bi

  • Hong-Hwa Lim

  • Kong-Peng Lam

  • July 8, 2026

  • 0 min

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  • 1

    G3BP1 binds TBK1 and IRF3, crucial for innate immune signaling and IFN-β production during dsRNA-triggered antiviral responses.

  • 2

    G3BP1 deficiency impairs TBK1-IRF3 complex formation, affecting IRF3 phosphorylation and nuclear translocation.

  • 3

    The C-terminal RGG region of G3BP1 is essential for its interaction with TBK1 and IRF3.

  • 4

    Arginine methylation of G3BP1 at residues R435 and R460 is critical for its binding to TBK1.

  • 5

    PRMT5 promotes symmetric arginine-dimethylation of G3BP1, enhancing its interaction with TBK1.

Original Source(s)

G3BP1 methylation by PRMT5 facilitates its recruitment of TBK1 for IRF3 activation during host response to foreign ribonucleic acids

  • by Wen Song, Susana Soo-Yeon Kim, Candice Yam, Joey Teo, Jyue Yuan Lim, Xuezhi Bi, Hong-Hwa Lim, Kong-Peng Lam

  • July 8, 2026

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