Impact of alpha-lipoic acid on salivary production in patients receiving radiotherapy for head and neck cancer: a randomized clinical study - Takeaways - MDSpire

Impact of alpha-lipoic acid on salivary production in patients receiving radiotherapy for head and neck cancer: a randomized clinical study

  • By

  • Fahimeh Anbari

  • Seyedeh Masoumeh Heydari

  • Sedigheh Bakhtiari

  • Sepehr Younesi Pour Masouleh

  • Samira Azghandi

  • Hoora Bakhtiyari

  • January 31, 2026

  • 0 min

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  • 1

    Alpha-lipoic acid (ALA) may mitigate radiation-induced salivary gland injury in head and neck cancer patients undergoing radiotherapy.

  • 2

    Radiotherapy often leads to hyposalivation and xerostomia, significantly impairing the quality of life for head and neck cancer patients.

  • 3

    The study was a double-blind, randomized, placebo-controlled trial involving 20 patients with confirmed head and neck cancer.

  • 4

    Participants receiving ALA showed significant improvement in salivary output compared to the control group.

  • 5

    The findings support ALA's potential as a therapeutic agent to preserve salivary gland function during head and neck radiotherapy.

Original Source(s)

Impact of alpha-lipoic acid on salivary production in patients receiving radiotherapy for head and neck cancer: a randomized clinical study

  • by Fahimeh Anbari, Seyedeh Masoumeh Heydari, Sedigheh Bakhtiari, Sepehr Younesi Pour Masouleh, Samira Azghandi, Hoora Bakhtiyari

  • January 31, 2026

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