CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis - Takeaways - MDSpire

CXCL10 rs8878 as a Genetic Marker for Immune Phenotypes Associated with T-Lymphocyte Maintenance and Survival in Sepsis

  • By

  • Birte Dyck

  • Andrea Witowski

  • Thilo Bracht

  • Malte Bayer

  • Patrick Thon

  • Dominik Ziehe

  • Tim Rahmel

  • Matthias Unterberg

  • Britta Westhus

  • Lars Palmowski

  • Hartmuth Nowak

  • Stefan Felix Ehrentraut

  • Jennifer Orlowski

  • Alexander von Busch

  • Alexander Zarbock

  • Nina Babel

  • Moritz Anft

  • Dietrich Henzler

  • Michael Adamzik

  • Lars Bergmann

  • Barbara Sitek

  • Björn Koos

  • Katharina Rump

  • July 17, 2026

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  • 1

    CXCL10 rs8878 genotype is linked to T cell dysregulation and 30-day survival in septic patients.

  • 2

    Carriers of the rs8878 AA genotype showed higher circulating T cell counts and improved survival compared to G-allele carriers.

  • 3

    Increased CXCL10 mRNA expression was observed in non-survivors with the AA genotype, indicating genotype-dependent regulation.

  • 4

    CXCL10 concentrations on day 1 correlated positively with inflammatory cytokines and inversely with total T cell counts.

  • 5

    The study suggests CXCL10 as a potential biomarker for risk stratification and a candidate target for immunomodulatory therapies in sepsis.

Original Source(s)

CXCL10 rs8878 identifies a genotype-associated immune phenotype linked to T-lymphocyte preservation and survival in sepsis

  • by Birte Dyck, Andrea Witowski, Thilo Bracht, Malte Bayer, Patrick Thon, Dominik Ziehe, Tim Rahmel, Matthias Unterberg, Britta Westhus, Lars Palmowski, Hartmuth Nowak, Stefan Felix Ehrentraut, Jennifer Orlowski, Alexander von Busch, Alexander Zarbock, Nina Babel, Moritz Anft, Dietrich Henzler, Michael Adamzik, Lars Bergmann, Barbara Sitek, Björn Koos, Katharina Rump

  • July 17, 2026

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